Publications & Awards

de Boer RA, Nijenkamp LLAM, Silljé HHW, Eijgenraam TR, Parbhudayal R, van Driel B, Huurman R, Michels M, Pei J, Harakalova M, van Lint FHM, Jansen M, Baas AF, Asselbergs FW, van Tintelen JP, Brundel BJJM, Dorsch LM, Schuldt M, Kuster DWD, van der Velden J (DOSIS consortium).
Strength of patient cohorts and biobanks for cardiomyopathy research.
Netherlands Heart Journal 2020

Eijgenraam TR, Boukens BJ, Boogerd CJ, Schouten EM, van de Kolk KWA, Stege NM, te Rijdt WP, Hoorntje ET, van der Zwaag PA, van Rooij E, van Tintelen JP, van den Berg MP, van der Meer P, van der Velden J, Silljé HHW, de Boer RA.
A novel mouse model of phospholamban p.(Arg14del)-associated cardiomyopathy develops heart failure and is unresponsive to standard heart failure therapy.
Scient Rep 2020, in press.

Parbhudayal RY, Harms HJ, Michels M, van Rossum AC, Germans T, van der Velden J.
Increased myocardial oxygen consumption precedes contractile dysfunction in hypertrophic cardiomyopathy caused by pathogenic TNNT2 gene variants.
JAHA: Journal of the American Heart Association 2020:e015316.

Nijenkamp LLAM, Bollen IAE, Niessen HWM, dos Remedios CG, Michels M,  Poggesi C, Ho CY, Kuster DWD, van der Velden J.
Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy.
Plos one 2020, in press.

Wijnker PJM, van der Velden J.
Mutation-specific pathology and treatment of hypertrophic cardiomyopathy in patients, mouse models and human engineered heart tissue.
Biochimica et Biophysica Acta – Molecular Basis of Disease 2020;23:165774.

Paul J.M. Wijnker, Vasco Sequeira, Diederik W.D. Kuster, and Jolanda van der Velden
Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits
Antioxid. Redox Signal. 2019. 31, 318–358.

MaritWiersma, Denise M.S. van Marion, Rob C.I. Wüst, Riekelt H. Houtkooper, Deli Zhang, Natasja M.S. de Groot, Robert H. Henning, and Bianca J.J.M. Brundel
Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation
Netherlands Heart Journal volume 27, pages117–126(2019)

H. G. van Velzen · A. F. L. Schinkel · R. W. J. van Grootel · M. A. van Slegtenhorst · J. van der Velden · M. Strachinaru · M. Michels
Five-year prognostic significance of global longitudinal strain in individualswith a hypertrophic cardiomyopathy genemutationwithout hypertrophic changes
Netherlands Heart Journal volume 27, pages117–126(2019)

Denise MS van Marion, Xu Hu, Deli Zhang, Femke Hoogstra-Berends, Jean-Paul G Seerden, Lizette Loen, Andre Heeres, Herman Steen, Robert H Henning, Bianca JJM Brundel
Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation
Drug Design, Development and Therapy 2019:13 345–364

Freyja H.M. van Lint, MD Brittney Murray, MS Crystal Tichnell, MGC Rob Zwart, BS Nuria Amat, MS Ronald H. Lekanne Deprez, PhD Sven Dittmann, PhD Birgit Stallmeyer, PhD Hugh Calkins, MD Jasper J. van der Smagt, MD Arthur van den Wijngaard, PhD Dennis Dooijes, PhD Paul A. van der Zwaag, MD, PhD Eric Schulze-Bahr, MD, PhD Daniel P. Judge, MD Jan D.H. Jongbloed, PhD J. Peter van Tintelen, MD, PhD Cynthia A. James, ScM, PhD
Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmosomal Variants Are Rarely De Novo
Circ Genom Precis Med. 2019;12:e002467.

Beau van Driela, Louise Nijenkamp, Roy Huurman, Michelle Michels, and Jolanda van der Velden
Sex differences in hypertrophic cardiomyopathy: new insights
Curr Opin Cardiol 2019, 34:000–000

Beau van Driel, Folkert W. Asselbergs, Rudolf A. de Boer, Albert C. van Rossum, J. Peter van Tintelen, Jolanda van der Velden en Michelle Michels
Hypertrofische cardiomyopathie
NED TIJDSCHR GENEESKD. 2019;163:D2790

Jolanda van der Velden and Ger J. M. Stienen
Cardiac disorders and pathophysiology of sarcomeric proteins
Physiol Rev 99: 381–426, 2019

Wouter P. te Rijdt, Angeliki Asimaki, Jan D.H. Jongbloed, Edgar T. Hoorntje, Elisabetta Lazzarini, Paul A. van der Zwaag, Rudolf A. de Boer, J. Peter van Tintelen, Jeffrey E. Saffitz, Maarten P. van den Berg, Albert J.H. Suurmeijer
Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy
Circ Genom Precis Med. 2019;12:e002436.

Mark Jansen, BS; Annette F. Baas, MD, PhD; Karin Y. van Spaendonck-Zwarts, MD, PhD; Amber S. Ummels, BS; Arthur van den Wijngaard, PhD; Jan D.H. Jongbloed, PhD; Marjon A. van Slegtenhorst, PhD; Ronald H. Lekanne Deprez, PhD; Marja W. Wessels, MD, PhD; Michelle Michels, MD, PhD; Arjan C. Houweling, MD, PhD; Edgar T. Hoorntje, MD; Paula J.T.M. Helderman-van den Enden, MD, PhD; Daniela Q.C.M. Barge-Schaapveld, MD, PhD; J. Peter van Tintelen, MD, PhD; Maarten P. van den Berg, MD, PhD; Arthur A.M. Wilde, MD, PhD; Hans K. Ploos van Amstel, PhD; Eric A.M. Hennekam, BS; Folkert W. Asselbergs, MD, PhD; Eric J.G. Sijbrands, MD, PhD; Dennis Dooijes, PhD
Mortality Risk Associated With Truncating Founder Mutations in Titin
Circ Genom Precis Med. 2019;12:e002436.

Xu Hu, Jin Li, Denise M.S. van Marion, Deli Zhang, Bianca J.J.M. Brundel
Heat shock protein inducer GGA*-59 reverses contractile and structural remodeling via restoration of the microtubule network in experimental Atrial Fibrillation
Journal of Molecular and Cellular Cardiology 134 (2019) 86–97

M. Michels, F. W. Asselbergs, J. van der Velden
Increasing sensitivity—acommon-sense approach?
Netherlands Heart Journal volume 27, pages287–288(2019)

Larissa M. Dorsch, , Maike Schuldt , Cristobal G. dos Remedios, Arend F. L. Schinkel, Peter L. de Jong, Michelle Michels, Diederik W. D. Kuster, Bianca J. J. M. Brundel and Jolanda van der Velden
Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy
Cells 2019, 8, 741

Bianca J.J.M. Brundel, Jin Li, Deli Zhang
Role of HDACs in cardiac electropathology: Therapeutic implications for atrial fibrillation
Biochimica et Biophysica Acta (BBA) – Molecular Cell Research (2019) 3:1867

Oyediran Akinrinade, Tiina Heliö, Ronald H. Lekanne Deprez, Jan D. H. Jongbloed, Ludolf G. Boven, Maarten P. van den Berg, Yigal M. Pinto, Tero-Pekka Alastalo, Samuel Myllykangas, Karin van Spaendonck-Zwarts, J. Peter van Tintelen, Paul A. van der Zwaag & Juha Koskenvuo
Relevance of Titin Missense and Non-Frameshifting Insertions/ Deletions Variants in Dilated Cardiomyopathy
Nature Scientific Reports (2019) 9:4093

Deli Zhang, Xu Hua, Jin Lia, Femke Hoogstra-Berends, Qiang Zhuang, Miguel A. Esteban, Natasja de Groot, Robert H. Henning, Bianca J.J.M. Brundel
Converse role of class I and class IIa HDACs in the progression of atrial fibrillation
Journal of Molecular and Cellular Cardiology 125 (2018) 39–49

Jolanda van der Velden, Carlo G. Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino F. Leite-Moreira, Manuel Mayr, Ines Falc~ao-Pires, Thomas Thum, Dana K. Dawson, Jean-Luc Balligand, and Stephane Heymans
Metabolic changes in hypertrophic cardiomyopathies: scientific update fromthe Working Group of Myocardial Function of the European Society of Cardiology
Cardiovascular Research (2018) 114, 1273–1280

Jasper Tromp, Arthur Mark Richards, Wan Ting Tay, Tiew-Hwa K. Teng, Poh Shuan Daniel Yeo, David Sim, Fazlur Jaufeerally, Gerard Leong, Hean Yee Ong, Lieng Hsi Ling, Dirk J. van Veldhuisen, Tiny Jaarsma, Adriaan A. Voors, Peter van der Meer, Rudolf A. de Boer and Carolyn S.P. Lam
N-terminal pro-B-type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure
ESC Heart Failure 2018; 5: 279–287

J. Peter van Tintelen, MD, PhD Yigal M. Pinto, MD, PhD
Additional Genetic Variants in Inherited Dilated Cardiomyopathy Just Another Brick in the Wall?
Circ. Genom Precis Med. 2018;11:e002249.

Navin Suthahar, Wouter C. Meijers, Herman H.W. Silljé, Jennifer E. Ho, Fu-Tong Liu, Rudolf A. de Boer
Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update
Theranostics 2018; 8(3): 593-609.

Navin Suthahar,Wouter C. Meijers, Jennifer E. Ho, Ron T. Gansevoort, Adriaan A. Voors, Peter van der Meer, Stephan J.L. Bakker, Stephane Heymans, Vanessa van Empel, Blanche Schroen, Pim van der Harst, Dirk J. van Veldhuisen, and Rudolf A. de Boer
Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population
European Journal of Heart Failure (2018) 20, 1205–1214

Louise L.A.M. Nijenkamp, MD Ilse A.E. Bollen, PhD Hannah G. van Velzen, MD Jessica A. Regan, MD Marjon van Slegtenhorst, PhD Hans W.M. Niessen, MD, PhD Arend F.L. Schinkel, MD, PhD Martina Krüger, PhD Corrado Poggesi, MD Carolyn Y. Ho, MD, PhD Diederik W.D. Kuster, PhD Michelle Michels, MD, PhD Jolanda van der Velden, PhD
Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy
Circ Heart Fail. 2018;11:e004133.

Murray B, Hoorntje ET, Te Riele ASJM, Tichnell C, van der Heijden JF, Tandri H, van den Berg MP, Jongbloed JDH, Wilde AAM, Hauer RNW, Calkins H, Judge DP, James CA, van Tintelen JP, Dooijes D.
Identification of sarcomeric variants in probands with a clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC)
J Cardiovasc Electrophysiol. 2018;29:1004–1009.

Wouter C. Meijers, MD Manuel Maglione, MD, PhD Stephan J.L. Bakker, MD, PhD Rupert Oberhuber, MD, PhD Lyanne M. Kieneker, MSc Steven de Jong, PhD Bernhard J. Haubner, MD, PhD Wouter B. Nagengast, MD, PhD Alexander R. Lyon, MD, PhD Bert van der Vegt, MD, PhD Dirk J. van Veldhuisen, MD, PhD B. Daan Westenbrink, MD, PhD Peter van der Meer, MD, PhD Herman H.W. Silljé, PhD Rudolf A. de Boer, MD, PhD
Heart Failure Stimulates Tumor Growth by Circulating Factors
Circulation. 2018;138:678–691.

Roelien A.M. Meijering, PhD, Marit Wiersma, PhD, Deli Zhang, PhD, Eva A.H. Lanters, MD, Femke Hoogstra-Berends, BSc, Jetse Scholma, PhD, Sander Diks, PhD, XiaoYan Qi, PhD, Natasja M.S. de Groot, MD, PhD,‡Stanley Nattel, MD, FHRS, Robert H. Henning, MD, PhD, Bianca J.J.M. Brundel
Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling
Heart Rhythm, Volume 15, Issue 11, 1708 – 1716

Jin Li, Deli Zhang, MaritWiersma and Bianca J. J. M. Brundel
Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Cells 2018, 7, 279; doi:10.3390/cells7120279

Magdalena Harakalova, Folkert W. Asselbergs
Systems analysis of dilated cardiomyopathy in the next generation sequencing era
WIREs Syst Biol Med. 2018;10:e1419.

Thomas M. Gorter, Dirk J. van Veldhuisen, Johann Bauersachs, Barry A. Borlaug, Jelena Celutkiene, Andrew J.S. Coats, Marisa G. Crespo-Leiro, Marco Guazzi, Veli-Pekka Harjola, Stephane Heymans, Loreena Hill, Mitja Lainscak, Carolyn S.P. Lam, Lars H. Lund, Alexander R. Lyon, Alexandre Mebazaa, Christian Mueller,Walter J. Paulus, Burkert Pieske, Massimo F. Piepoli, Frank Ruschitzka, Frans H. Rutten, Petar M. Seferovic, Scott D. Solomon, Sanjiv J. Shah, Filippos Triposkiadis, RolfWachter, Carsten Tschöpe, and Rudolf A. de Boer
Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology
European Journal of Heart Failure (2018) 20, 16–37

Bertrand Favre, PhD Nadja Begré, MSc Luisa Marsili, MD J. Peter van Tintelen, MD, PhD Luca Borradori, MD
Desmoplakin Gene Variants and Risk for Arrhythmogenic Cardiomyopathy. Usefulness of a Functional Biochemical Assay
Circ Genom Precis Med. 2018;11:e002241.

Larissa M. Dorsch & Maike Schuldt & Dora Knežević & Marit Wiersma & Diederik W. D. Kuster & Jolanda van der Velden & Bianca J. J. M. Brundel
Untying the knot: protein quality control in inherited cardiomyopathies
Pflugers Arch – Eur J Physiol 471, 795–806 (2019)

Laurens P. Bosman, MD, Arjan Sammani, BSc, Cynthia A. James, PhD, ScM, Julia Cadrin-Tourigny, MD, Hugh Calkins, MD, FHRS, J. Peter van Tintelen, MD, PhD, Richard N.W. Hauer, MD, PhD, Folkert W. Asselbergs, MD, PhD, Anneline S.J.M. te Riele
Predicting arrhythmic risk in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis
Heart Rhythm 2018;15:1097–1107

Antoine Bondue, Eloisa Arbustini, Anna Bianco, Michele Ciccarelli, Dana Dawson, Matteo De Rosa, Nazha Hamdani, Denise Hilfiker-Kleiner, Benjamin Meder, Adelino F. Leite-Moreira, Thomas Thum, Carlo G. Tocchetti, Gilda Varricchi, Jolanda Van der Velden, RoddyWalsh, and Stephane Heymans
Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from theWorking Group of Myocardial Function of the European Society of Cardiology
Cardiovascular Research (2018) 114, 1287–1303

Vijeta Bhambhani, Jorge R. Kizer, Joao A.C. Lima, Pim van der Harst, Hossein Bahrami, Matthew Nayor, Christopher R. de Filippi, Danielle Enserro, Michael J. Blaha, Mary Cushman, Thomas J. Wang, Ron T. Gansevoort, Caroline S. Fox, Hanna K. Gaggin,Willem J. Kop, Kiang Liu, Ramachandran S. Vasan, Bruce M. Psaty, Douglas S. Lee, Frank P. Brouwers, Hans L. Hillege, Traci M. Bartz, Emelia J. Benjamin, Cheeling Chan, Matthew Allison, Julius M. Gardin, James L. Januzzi Jr, Daniel Levy, David M. Herrington,Wiek H. van Gilst, Alain G. Bertoni, Martin G. Larson, Rudolf A. de Boer, John S. Gottdiener, Sanjiv J. Shah, and Jennifer E. Ho
Predictors and outcomes of heart failure with mid-range ejection fraction
European Journal of Heart Failure (2018) 20, 651–659

Sonia R. Singh, PhD, Antonia T.L. Zech, MSc, Birgit Geertz, Silke Reischmann-Düsener, Hanna Osinska, PhD, Maksymilian Prondzynski, MSc, Elisabeth Krämer, Qinghang Meng, PhD, Charles Redwood, PhD, Jolanda van der Velden, PhD, Jeffrey Robbins, PhD, Saskia Schlossarek, PhD, and Lucie Carrier, PhD
Activation of autophagy ameliorates cardiomyopathy in Mybpc3-targeted knock-in mice
Circ Heart Fail. 2017 October; 10(10).

Baerbel Klauke, Anna Gaertner-Rommel, Uwe Schulz, Astrid Kassner, Edzard zu Knyphausen, Thorsten Laser, Deniz Kececioglu, Lech Paluszkiewicz, Ute Blanz, Eugen Sandica, Antoon J. van den Bogaerdt, J. Peter van Tintelen, Jan Gummert, Hendrik Milting
High proportion of genetic cases in patients with advanced cardiomyopathy including a novel homozygous Plakophilin 2-gene mutation
 PLoS ONE 2017 12(12): e0189489.

Sonia R. Singh, PhD, Antonia T.L. Zech, MSc, Birgit Geertz, Silke Reischmann-Düsener, Hanna Osinska, PhD, Maksymilian Prondzynski, MSc, Elisabeth Krämer, Qinghang Meng, PhD, Charles Redwood, PhD, Jolanda van der Velden, PhD, Jeffrey Robbins, PhD, Saskia Schlossarek, PhD, and Lucie Carrier
Activation of autophagy ameliorates cardiomyopathy in Mybpc3-targeted knock-in mice
Circ Heart Fail. 2017 October; 10(10)

M. LINSCHOTEN, A. J. TESKE, MD, PhD, A. F. BAAS, MD, PhD, A. VINK, MD, PhD, D. DOOIJES, PhD, H. F. BAARS, MD, AND F. W. ASSELBERGS, MD, PhD
Truncating Titin (TTN) Variants in Chemotherapy-Induced Cardiomyopathy
Journal of Cardiac Failure Vol. 23 No. 6 2017

Robert H. Henning & Bianca J. J. M. Brundel
Proteostasis in cardiac health and disease
Nature Reviews Cardiology volume 14, pages637–653(2017)

Shahrzad Sepehrkhouy, MD, Johannes M. I. H. Gho, MD, PhD, Rene van Es, PhD, Magdalena Harakalova, MD, PhD, Nicolaas de Jonge, MD, PhD, Dennis Dooijes, PhD, Jasper J. van der Smagt, MD, PhD, Marc P. Buijsrogge, MD, PhD, Richard N. W. Hauer, MD, PhD, Roel Goldschmeding, MD, PhD, Roel A. de Weger, PhD, Folkert W. Asselbergs, MD, PhD, Aryan Vink, MD, PhD
Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies
Heart Rhythm 2017;14:1024–1032

Wouter P. te Rijdt, Z. Joy van der Klooster, Edgar T. Hoorntje, Jan D.H. Jongbloed, Paul A. van der Zwaag, Folkert W. Asselbergs, Dennis Dooijes, Rudolf A. de Boer, J. Peter van Tintelen, Maarten P. van den Berg, Aryan Vink, Albert J.H. Suurmeijer
Phospholamban immunostaining is a highly sensitive and specific method for diagnosing phospholamban p.Arg14del cardiomyopathy
Cardiovascular Pathology 30 (2017) 23–26

van Velzen HG, Schinkel AFL, Oldenburg RA, van Slegtenhorst MA, Frohn – Mulder IME, van der Velden J, Michels M.
Clinical characteristics and long-term outcome of hypertrophic cardiomyopathy in individuals with a MYBPC3 founder mutation.
Circulation: Cardiovascular Genetics 2017, in press.

Marit Wiersma, PhD;* Roelien A. M. Meijering, PhD;* Xiao-Yan Qi, PhD; Deli Zhang, PhD; Tao Liu, MD; Femke Hoogstra-Berends, BSc; Ody C. M. Sibon, PhD; Robert H. Henning, MD, PhD; Stanley Nattel, MD; Bianca J. J. M. Brundel, PhD
Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation
J Am Heart Assoc. 2017;6:e006458.

Hoorntje ET, Bollen IA, Barge-Schaapveld DQ, van Tienen FH,  te Meerman GJ, Jansweijer JA, van Essen AJ, Volders PG, Constantinescu AA, van den Akker PC, van Spaendonck-Zwarts KY, OldenburgRA, Marcelis C, van der Smagt JJ, Hennekam EA, Vink A, Bootsma M, Aten E, Wilde AA, van den Wijngaard A, Broers JL, Jongbloed JD, van der Velden J, van den Berg MP, van Tintelen JP.
LMNA-related cardiac disease: late onset with a variable and mild phenotype in a large cohort of patients with the LMNA p.(Arg331Gln) founder mutation.
Circulation: Cardiovascular Genetics 2017, in press.

van Deel ED, Najafi A, Fontoura D, Valent E, Goebel M, Kardux K, Falcão-Pires I, van der Velden J.
In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes.
Journal of Physiology 2017, in press. DOI: 10.1113/JP274460

Bollen IAE, Schuldt M, Harakalova M, Vink A, Asselbergs FW, Pinto JR, Krüger M, Kuster DWD, van der Velden J.
Genotype-specific pathogenic effects in human dilated cardiomyopathy.
Journal of Physiology 2017, in press. doi: 10.1113/JP274145

Michels M, Olivotto I, Asselbergs FW, van der Velden J.
Life-long tailoring of management for patients with hypertrophic cardiomyopathy: awareness and decision-making in changing scenarios.
Netherlands Heart Journal 2016, in press.