Larissa DorschPhD Student WP2

Research motivation for CVON-DOSIS

The internship in the van der Velden group in 2013 has sparked Larissa’s interest in cardiac research. In her bachelor thesis, she described the phenotype of knocking down Talin2a in zebrafish which results in contractile dysfunction and as a consequence, in heart failure. During her PhD studies, she uses established cardiomyocyte and Drosophila models to introduce the human mutations causing inherited cardiomyopathies. By conducting biochemical analysis with the mutants, she aims to determine the contribution of protein quality control system to the development of inherited cardiomyopathies. Besides unravelling mechanisms leading to cardiomyopathies, she would like to identify potential innovative treatment strategies in the experimental model systems. Therefore, she plans to test whether normalization of protein quality control represents a therapy to prevent mutation-induced cellular dysfunction. She decided to join the CVON-project because of the broad and different expertise of the involved researchers and the translation of the unravelled findings.

 


 

Education

2011-2014

Bachelor of Science “Molecular Medicine”
University Ulm, Germany
Bachelor thesis: Loss of Talin2a leads to heart failure in the in vivo model zebrafish (Molecular Cardiology, Prof. S. Just, Ulm University)

2014-2016

Master of Science “Biomedical Science”
Philipps University Marburg, Germany
Master thesis: Analysis of the responsible interaction domains between Plakophilin 3 (PKP3) and Peptidyl-Prolyl Cis-Trans Isomerase NIMA-interacting 1 (PIN1) (Dep. of Pathology, Prof. R. Moll, Philipps University Marburg)
Since 2016

PhD Student in the Dep. of Physiology, VU University Medical Center Amsterdam, Group Bianca Brundel (WP 2)