Research motivation for CVON-DOSIS
The interest in the molecular mechanisms of diseases was the reason for Maike to study “Molecular Medicine”. The research oriented study gave the opportunity for many research internships in different fields and techniques.
During the Master studies Maike was mainly interested in cardiovascular research. She decided to write her master thesis in Amsterdam in the group of Jolanda van der Velden and continues now her work on Hypertrophic Cardiomyopathy as a PhD student within the CVON DOSIS project.
In WP3 Maike is now studying the direct effect of the mutant protein dose and the mutation location on myofilament function. Therefore she is introducing different amounts of recombinant mutant protein into permeabilized single human cardiomyocytes followed by isometric force measurements. With this technique the amount of mutant protein that is needed to affect sarcomere function can be determined. Furthermore she will use adenoviruses encoding for different sarcomeric mutations to elucidate their effect on intact cardiomyocytes and to link mutant protein dose with protein quality control.
Bachelor of Science “Molecular Medicine”, Georg-August-University Göttingen, Germany
Bachelor thesis: miR-449 depletion leads to chronic obstructive pulmonary disease in a mouse model (Molecular Oncology, Prof. M. Dobbelstein/Dr. Muriel Lizé, University of Göttingen)
Master of Science “Molecular Medicine”, Georg-August-University Göttingen, Germany
Master thesis: The contribution of glucocorticoids as secondary factors in Hypertrophic Cardiomyopathy (Dept. of Physiology, Prof. J. van der Velden/Dr. Diederik Kuster, VU University Medical Center Amsterdam)
PhD student in the Dept. of Physiology, VU University Medical Center Amsterdam, Group Jolanda van der Velden